In this adventure game you play as Travis Touchdown, a normal guy (with an otaku geek streak to him) who wins a Beam Katana through an online auction and uses the weapon to start a new career as a professional killer. One day, an assassin named Helter Skelter appears before Travis and the two face off in a battle. Travis emerges victorious and finds himself in the presence of Silvia Christel, a mysterious French woman who claims to be an agent with the UAA. Silvia gives Travis official rank of 11 in the organization. Now, it's up to you to become #1.

No More Heroes takes place in the city of Santa Destroy, and you are free to explore the town to your liking, taking on missions large and small to collect money and purchase new weapons as you work up towards the 10 main killing contracts. Gameplay is all about using your Beam Katana (via Wii remote) to defeat enemies.

• Free roaming world in which Travis can move around on foot or motorcycle.
• Advance through the game through part time jobs to earn more money to buy additional weapons.
• Unique Wii controller functionality with the Remote controlling the katana beam and the Nunchuk moving Travis.
• Numerous side quests including part-time jobs exist for Travis to gain additional weapons and to make money
• Wide range of swords available which can be recharged by shaking the Wii Remote.